0 0 0
This online shop is using cookies to give you the best shopping experience. Thereby for example the session information or language setting are stored on your computer. Without cookies the range of the online shop's functionality is limited. If you don't agree, please click here.
Tumor Dormancy, Quiescence, and Senescence Vol. 3

Hayat Tumor Dormancy, Quiescence, and Senescence Vol. 3

Aging Cancer and Noncancer Pathologies

ISBN: 978-94-017-9324-7

Edition: 1st Ed.

Publication date: September 2014

Cover: Hardcover

Pages: 170 p.

Illustrations: 19 ill.

Publisher: Springer

Delivery times, dependent on availability and publisher: between 2 and 14 days from when you complete the order.

Description

  • Discusses the effects of senescence and dormancy in breast cancer, ovarian cancer and leukemia, as well as in cardiovascular diseases
  • Advances the body of knowledge of cancer cell regression, including possible use of pro senescence therapy as an alternative to surgery, chemotherapy or radiation therapy
  • Includes the contributions of some 26 experts representing seven different countries

This third volume in the series Tumor Dormancy, Quiescence, and Senescence discusses the role of tumor dormancy and senescence in a number of diseases, including breast cancer, ovarian cancer, and leukemia. The contents are organized under five subheadings: General Applications, Role in Breast Cancer, Role in Ovarian Cancer, Role in Leukemia and Role in Cardiovascular Disease.

The first section includes basic information on the definition of dormancy, how cells become senescent, and what they do, along with an appraisal of the current state of research on dormancy. Section Two explores dormancy in breast cancer, including the progression of hormone-dependent mammary tumors after dormancy. Section Three details the resistance of Type II ovarian tumors, in which the resistant tumor cell population persists after chemotherapy in a state of dormancy, with recurrent tumors arising upon transformation of such dormant cells back to malignant growth. This section explains how lineage, histological subtypes, and grade influence the differential response of ovarian cancer resistance to platinum drugs. The fourth section explores leukemia, discussing regulation of the promyelocytic leukemia protein and its role in premature senescence. The final section explores the role of senescence and autophagy in age-related cardiovascular diseases, and the observation that autophagy seems to retard cardiac senescence.

Like the two preceding volumes in the series, Volume 3 stands out for its comprehensive approach, its roster of some 26 expert contributors representing seven different countries and its up-to-date review of leading-edge technology and methods.