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Alternatives for Dermal Toxicity Testing

Eskes, van Vliet, Maibach Alternatives for Dermal Toxicity Testing

ISBN: 978-3-319-50351-6

Edition: 1st Ed.

Publication date: December 2017

Cover: Hardcover

Pages: 592p.

Illustrations: 92 ill.

Publisher: Springer

Delivery times, dependent on availability and publisher: between 2 and 14 days from when you complete the order.

Description

  • Provides in-depth information on the alternatives to animal testing
  • Identifies the most suitable test method(s) for specific uses and endpoints
  • Describes the regulatory acceptance, protocols, performance, limitations, and applicability of each method
  • Explains the role of individual methods within testing strategies

This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol. The closing section addresses areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, novel complex skin models, and high-throughput screening techniques.