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Vitamin D in Chronic Kidney Disease

Urena Torres, Cozzolino, Vervloet Vitamin D in Chronic Kidney Disease

ISBN: 978-3-319-32505-7

Auflage: 1st Ed.

Erscheinungsdatum: Oktober 2016

Einband: Hardcover

Seitenzahl: 574 p.

Illustrationen: 66 ill.

Verlag: Springer

Lieferzeit ab Ihrer Bestellung: 2-14 Tage je nach Lieferbarkeit und Verlag

Beschreibung

  • This book will focus on vitamin D in Chronic Kidney Disease states   Discusses recent insights on vitamin D metabolism as well as its association with a diversity of non-skeletal complications, among them cardiovascular disease, diabetes mellitus, multiple sclerosis, cancer, tuberculosis, and immune system dysfunction
  • New players in the regulation of vitamin synthesis and degradation have been identified and largely explored in case of CKD including FGF23 and klotho

Vitamin D deficiency, circulating levels lower than 15 ng/ml, is an epidemic disease worldwide with  more than a billion people suffering of it in the beginning of the 21-century. Besides its impact on mineral and bone metabolism, these low vitamin D levels are also associated with a diversity of non-skeletal complications, among them cardiovascular disease, diabetes mellitus, multiple sclerosis, cancer, tuberculosis, and immune system dysfunction. Chronic Kidney Disease is also a very common disease, affecting more than 10% of the world population, ranging from stage 1 to stage 5 before dialysis. Approximately 1% of the population in industrialized countries is affected by end-stage renal disease (ESRD), needing a renal replacement therapy either hemodialysis or peritoneal dialysis, and ultimately by renal transplantation. Those CKD patients are more susceptible to exhibit reduced vitamin D stocks. Consequently, more than eighty percent of CKD patients have either insufficient or deficient vitamin D levels for multiple reasons.