Foucar, Viswanatha, Wilson Non-Neoplastic Disorders of Bone Marrow

This Fascicle on non-neoplastic disorders is devoted to the assessment of bone marrow in pediatric and adult patients. Although the emphasis is clearly on the successful diagnosis of non-neoplastic bone marrow disorders, neoplastic processes are briefly highlighted in discussions of differential diagnostic considerations.

The early chapters focus on hematopoiesis, bone marrow topobiology, indications for bone marrow examination, and the utility of specific types of bone marrow specimens in diagnostic assessment. It is challenging to focus on bone marrow findings in non-neoplastic disorders because of the critical role of peripheral blood smear findings in establishing a diagnosis in many non-neoplastic hematologic conditions. Consequently chapter 3 focuses almost exclusively on a clinical/peripheral blood approach to non-neoplastic hematologic disorders. In addition, blood findings are integrated with the bone marrow pathology in each chapter.

Lineage-based non neoplastic erythroid, myeloid, megakaryocytic, and lymphoid disorders are discussed as well as bone marrow findings in patients with systemic, nonhematologic disorders. A standardized format is used to the best extent possible for each chapter, with an enphasis on categorizing disorders based on patient age, constitutional versus acquired conditions, and pathogenetic mechanism. Because of this combined lineage-based and disease-based approach, there is some unavoidable overlap of content between chapters. Cross referencing refers the reader to the specific chapter with the most comprehensive discussion.

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